Towards improved blood purification therapies using new (bio)artificial kidney devices
Avondlezing door prof.dr. Dimitrios Stamiatalis (UTwente) georganiseerd door de Bossche Chemische Kring.
Samenvatting
Hemodialysis is a widely available and well-established treatment for patients with End Stage Renal Disease (ESRD). The therapy requires patients to visit the dialysis centres 3-4 times a week, which is for these patients a great social and psychological burden. Major drawbacks of the therapy are:
- the poor removal of middle-sized molecules and protein-bound uremic solutes and
- the non-continuous treatment, causing large fluctuations in water balance and uremic wastes of the patients.
In this presentation, we will discuss two new concepts for removing a broad range of uremic toxins:
Mixed matrix membranes (MMM), which combine the benefits of diffusion and /or convection, provided by the membrane structure, and of adsorption, achieved by activated carbon particles dispersed through the membrane;
Bioartificial kidney, based on a “living membrane” consisting of a tight renal cells monolayer with preserved functional organic ion transporters, on suitable artificial membranes. The cell monolayer is used for active removal of the uremic solutes mimicking the function of the kidney proximal tubule.
Introducé(e)s zijn van harte welkom.
Graag vooraf bericht als u verwacht te komen.
Stuur daartoe een mail naar tcj.gribnau@planet.nl.
Meer informatie over deze en andere lezingen is te vinden op www.beceka.info.
